A late winter storm dumped 19 to 52 inches on parts of Colorado, Wyoming and Nebraska on Sunday.
Denver International Airport reported canceling 2,000 flights on Saturday and Sunday.
Officials have issued road closures and avalanche warnings in parts of Colorado, Wyoming and Nebraska.
This storm has been described as a "historic and crippling" winter storm by The National Weather Service, warning that travel is dangerous and should be avoided until Monday.
The state of Wyoming has been particularly hard hit with most major roads being closed, including into its main cities, Cheyenne and Casper.
The show is so severe that the Wyoming Department of Transportation halted snow plowing operations in the Casper area on Sunday due to a lack of visibility.
"We had several plows drive off the roadway due to limited-to-zero visibility," the agency said on its Facebook page.
Weather reports announced that over two feet (61 centimeters) of snow had fallen outside Cheyenne, while towns at the higher elevations reported 52 inches (1.3 meters) of snow in a 24-hour period.
At a truck stop in Cheyenne, employees said 98 trucks were stranded.
The Interstate 80 highway was closed across southern Wyoming and into Nebraska, where 19 inches (48 centimeters) of snow have fallen.
Public schools in Denver, Cheyenne and Casper will be closed on Monday, along with some government offices.
Denver International Airport received 19 inches of snow as of Sunday noon and remains closed.
Thousands of customers throughout the region are without electricity and avalanche warnings have been issued by authorities.